Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Suppressive parenteral antibiotic therapy with beta-lactams may be necessary in patients with Gram-negative bone and joint infection (BJI). Subcutaneous drug administration can facilitate this therapy in outpatient setting, but there is limited information about this practice. We have developed an o...

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Bibliographic Details
Main Authors: Sylvain Goutelle, Anne Conrad, Cécile Pouderoux, Evelyne Braun, Frédéric Laurent, Marie-Claude Gagnieu, Sabine Cohen, Jérôme Guitton, Florent Valour, Tristan Ferry
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Medicine
Subjects:
prosthetic-joint infection
antimicrobial therapy
pharmacodynamics
pharmacokinetics
beta-lactam
subcutaneous administration
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.583086/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.583086/full

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