AT1 receptor blocker, but not an ACE inhibitor, prevents kidneys from hypoperfusion during congestive heart failure in normotensive and hypertensive rats

Abstract To provide novel insights into the pathogenesis of heart failure-induced renal dysfunction, we compared the effects of ACE inhibitor (ACEi) and AT1 receptor blocker (ARB) on systemic and kidney hemodynamics during heart failure in normotensive HanSD and hypertensive transgenic (TGR) rats. H...

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Bibliographic Details
Main Authors: Vojtech Kratky, Zdenka Vanourkova, Matus Sykora, Barbara Szeiffova Bacova, Zdenka Hruskova, Sona Kikerlova, Zuzana Huskova, Libor Kopkan
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83906-6