Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients’ Brain in a Dish

Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients’ Brain in a Dish

Mitochondrial diseases are a heterogeneous group of rare genetic disorders that can be caused by mutations in nuclear (nDNA) or mitochondrial DNA (mtDNA). Mutations in mtDNA are associated with several maternally inherited genetic diseases, with mitochondrial dysfunction as a main pathological featu...

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Bibliographic Details
Main Authors: Suleva Povea-Cabello, Marina Villanueva-Paz, Juan M. Suárez-Rivero, Mónica Álvarez-Córdoba, Irene Villalón-García, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, José A. Sánchez-Alcázar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
mitochondrial diseases
mtDNA
disease modeling
direct reprogramming
induced neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.610764/full

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https://www.frontiersin.org/articles/10.3389/fgene.2020.610764/full

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