Niflumic Acid Inhibits Goblet Cell Degranulation in a Guinea Pig Asthma Model

Niflumic Acid Inhibits Goblet Cell Degranulation in a Guinea Pig Asthma Model

Background: Human Ca2+-activated Cl ion channel 1 (hCLCAl) is expressed in goblet cell hyperplasia in the airway of asthmatics, and murine CLCA3 is associated with antigen-sensitized and IL-13-induced goblet cell metaplasia in mice. However, the role of CLCA in goblet cell degranulation is not fully...

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Bibliographic Details
Main Authors: Mitsuko Kondo, Junko Nakata, Naoki Arai, Takehiro Izumo, Etsuko Tagaya, Kiyoshi Takeyama, Jun Tamaoki, Atsushi Nagai
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Allergology International
Subjects:
calcium-activated chloride channel
degranulation
goblet cells
MUC5AC
niflumic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015302033

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http://www.sciencedirect.com/science/article/pii/S1323893015302033

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