Rag defects and thymic stroma: lessons from animal models

Rag defects and thymic stroma: lessons from animal models

Thymocytes and thymic epithelial cells (TECs) cross-talk is essential to support T-cell development and preserve thymic architecture and maturation of TECs and Foxp3+ natural regulatory T (nTreg) cells. Accordingly, disruption of thymic lymphostromal cross-talk may have major implications on the thy...

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Bibliographic Details
Main Authors: Veronica eMarrella, Pietro Luigi Poliani, Luigi Daniele Notarangelo, Anna eVilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
Central Tolerance
Thymus
Rag deficiency
thymic reconstitution
thymic crosstalk
Omenn and leaky SCID models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00259/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00259/full

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