A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties

A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties

Phenotypic screening is an ideal strategy for the discovery of novel bioactive molecules. Using a customized high-throughput screening (HTS) assay employing primary T lymphocytes, we screened a small library of 4,398 compounds with unknown biological function/target to identify compounds eliciting i...

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Bibliographic Details
Main Authors: Abed El-Hakim El-Kadiry, Jamilah Abusarah, Yun Emma Cui, Nehme El-Hachem, Ian Hammond-Martel, Hugo Wurtele, Sini Thomas, Maryam Ahmadi, Mohammad Balood, Sébastien Talbot, Moutih Rafei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
HTS
small molecule
sulfonyl compound
T cells
cancer
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00237/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00237/full

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