Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study.

BACKGROUND:Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) are far more prevalent in European Americans than in African Americans. Hypothesizing that this racial disparity in prevalence might represent a genetic susceptibility, we used an admixture mapping approach to interrogate d...

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Main Authors: Xiangqing Sun, Apoorva K Chandar, Marcia I Canto, Prashanthi N Thota, Malcom Brock, Nicholas J Shaheen, David G Beer, Jean S Wang, Gary W Falk, Prasad G Iyer, Julian A Abrams, Medha Venkat-Ramani, Martina Veigl, Alexander Miron, Joseph Willis, Deepa T Patil, Ilke Nalbantoglu, Kishore Guda, Sanford D Markowitz, Xiaofeng Zhu, Robert Elston, Amitabh Chak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5657624?pdf=render