The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus

The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus

Abstract Background Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported th...

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Bibliographic Details
Main Authors: Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F. Outeiro, Nela Pivac, Fran Borovecki
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Type 2 diabetes mellitus
Insulin detemir
COMT Val108/158Met polymorphism
DBH-1021C/T polymorphism
Hemoglobin A1c (HbA1c)
BMI
Online Access:http://link.springer.com/article/10.1186/s13098-017-0295-0

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http://link.springer.com/article/10.1186/s13098-017-0295-0

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