Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes

Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes

Expression of the pro-angiogenic vascular endothelial growth factor (VEGF) stimulates angiogenesis and correlates with the progression of osteoarthritis. Mechanical joint loading seems to contribute to this cartilage pathology. Cyclic equibiaxial strains of 1% to 16% for 12 h, respectively, induced...

Full description

Bibliographic Details
Main Authors: Rainer Beckmann, Astrid Houben, Mersedeh Tohidnezhad, Nisreen Kweider, Athanassios Fragoulis, Christoph J. Wruck, Lars O. Brandenburg, Benita Hermanns-Sachweh, Mary B. Goldring, Thomas Pufe, Holger Jahr
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:International Journal of Molecular Sciences
Subjects:
VEGF-A
VEGFR-1/FLT-1
sVEGFR-1/FLT-1
cyclic stretch
strain
human chondrocyte
C-28/I2
Online Access:http://www.mdpi.com/1422-0067/15/9/15456

Internet

http://www.mdpi.com/1422-0067/15/9/15456

Similar Items