Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

<p>Abstract</p> <p>Background</p> <p>Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation. Because of the significant prevalence of insulin resista...

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Bibliographic Details
Main Authors: Sabatini Mary E, Guo Lankai, Lynch Maureen P, Doyle Joseph O, Lee HoJoon, Rueda Bo R, Styer Aaron K
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Journal of Ovarian Research
Subjects:
polycystic ovarian syndrome
metformin
hyperinsulinemia
oocyte
superovulation
Online Access:http://www.ovarianresearch.com/content/4/1/8

Internet

http://www.ovarianresearch.com/content/4/1/8

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