In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression

Abstract Background The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating multiple genes under such multifactorial conditions. Methods and results MiR-138-5p is overexpressed in pulmonar...

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Bibliographic Details
Main Authors: Hélène Le Ribeuz, Audrey Courboulin, Maria-Rosa Ghigna, Mélanie Lambert, Aurélie Hautefort, Marc Humbert, David Montani, Sylvia Cohen-Kaminsky, Frédéric Perros, Fabrice Antigny
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Subjects:
miR-138
PAH
KCNK3
Proliferation
SLC45A3
Online Access:http://link.springer.com/article/10.1186/s12931-020-01444-7

Internet

http://link.springer.com/article/10.1186/s12931-020-01444-7

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