High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia.

High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia.

It has been recently shown that DNA methyl transferase overexpression is correlated with unfavourable prognosis in human malignancies while methylation deregulation remains a hallmark that defines acute myeloid leukemia (AML). The oncogenic transcription factor EVI1 is involved in methylation deregu...

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Bibliographic Details
Main Authors: Sandrine Hayette, Xavier Thomas, Laurent Jallades, Kaddour Chabane, Carole Charlot, Isabelle Tigaud, Sophie Gazzo, Stéphane Morisset, Pascale Cornillet-Lefebvre, Adriana Plesa, Sarah Huet, Aline Renneville, Gilles Salles, Franck Emmanuel Nicolini, Jean-Pierre Magaud, Mauricette Michallet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519733?pdf=render

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http://europepmc.org/articles/PMC3519733?pdf=render

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