ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

Abstract Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerative diseases in Caucasian case-control cohorts: 2742 ...

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Bibliographic Details
Main Authors: Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Neurodegeneration
Subjects:
ABI3
PLCG2
Alzheimer’s disease (AD)
Progressive supranuclear palsy (PSP)
Parkinson’s disease (PD)
Dementia with Lewy bodies (DLB)
Online Access:http://link.springer.com/article/10.1186/s13024-018-0289-x

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http://link.springer.com/article/10.1186/s13024-018-0289-x

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