Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

Background: Epidemiological studies have shown Per- and polyfluoroalkyl substances (PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as steatosis and cardiometabolic disorders. However, the majority of mechanistic studies rely on single chemical exposures instea...

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Bibliographic Details
Main Authors: Katherine Roth, Zhao Yang, Manisha Agarwal, Wendy Liu, Zheyun Peng, Ze Long, Johnna Birbeck, Judy Westrick, Wanqing Liu, Michael C. Petriello
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Environment International
Subjects:
PFAS toxicity
Per- and polyfluoroalkyl substances
Liver injury
Cardiometabolic disease
Hyperlipidemia
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412021004682

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http://www.sciencedirect.com/science/article/pii/S0160412021004682

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