Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies

Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies

A highly virulent strain (Hypr) of tick-borne encephalitis virus (TBEV) was serially subcultured in the mammalian porcine kidney stable (PS) and <i>Ixodes ricinus</i> tick (IRE/CTVM19) cell lines, producing three viral variants. These variants exhibited distinct plaque sizes and virulenc...

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Bibliographic Details
Main Authors: Renata Helmová, Václav Hönig, Hana Tykalová, Martin Palus, Lesley Bell-Sakyi, Libor Grubhoffer
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Viruses
Subjects:
TBEV
host alternation
neuroinvasiveness
genome mutation
quasispecies
flavivirus adaptation
Online Access:https://www.mdpi.com/1999-4915/12/8/902

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https://www.mdpi.com/1999-4915/12/8/902

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