The influence of PFK-II overexpression on neuroblastoma patients’ survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4

The influence of PFK-II overexpression on neuroblastoma patients’ survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4

Abstract Background/Aim During cancer progression metabolic reprogramming is observed in parallel to the alternation in transcriptional profiles of malignant cells. Recent studies suggest that metabolic isoenzymes of phosphofructokinase II (PFK-II) – PFKFB3 and PFKFB4, often induced in hypoxic envir...

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Bibliographic Details
Main Authors: Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz, Kinga A. Kocemba-Pilarczyk
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cancer Cell International
Subjects:
Phosphofructokinase II
PFKFB3
PFKFB4
Cancer progression
Overall survival
Neuroblastoma
Online Access:http://link.springer.com/article/10.1186/s12935-019-1005-9

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http://link.springer.com/article/10.1186/s12935-019-1005-9

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