The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.

The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.

<h4>Background</h4>Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1. We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza.<h4>Met...

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Bibliographic Details
Main Authors: Jorge M Tolosa, Kristy S Parsons, Philip M Hansbro, Roger Smith, Peter A B Wark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0118629

Internet

https://doi.org/10.1371/journal.pone.0118629

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