The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.
<h4>Background</h4>Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1. We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza.<h4>Met...
Main Authors: | Jorge M Tolosa, Kristy S Parsons, Philip M Hansbro, Roger Smith, Peter A B Wark |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0118629 |
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