Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma

Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma

The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and meta...

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Bibliographic Details
Main Authors: Johannes C. van der Mijn, Leiping Fu, Francesca Khani, Tuo Zhang, Ana M. Molina, Christopher E. Barbieri, Qiuying Chen, Steven S. Gross, Lorraine J. Gudas, David M. Nanus
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319304127

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http://www.sciencedirect.com/science/article/pii/S1936523319304127

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