Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis

Post-translational modifications such as glycosylation play an important role in the functions of homeostatic proteins, and are critical driving factors of several diseases; however, the role of glycosylation in autoimmune hepatitis is poorly understood. Here, we established an O-GlcNAc glycosylatio...

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Bibliographic Details
Main Authors: Xiaohua Hao, Yufeng Li, Jianwen Wang, Jiali Ma, Shuli Zhao, Xiaohui Ye, Lingling He, Junru Yang, Meixin Gao, Fan Xiao, Hongshan Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02089/full