Inferring fitness landscapes and selection on phenotypic states from single-cell genealogical data.

Recent advances in single-cell time-lapse microscopy have revealed non-genetic heterogeneity and temporal fluctuations of cellular phenotypes. While different phenotypic traits such as abundance of growth-related proteins in single cells may have differential effects on the reproductive success of c...

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Bibliographic Details
Main Authors: Takashi Nozoe, Edo Kussell, Yuichi Wakamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5360348?pdf=render