Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction, the quinols—if not conjugated—re-oxidizes sponta...

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Bibliographic Details
Main Authors: Monivan Chhour, Pierre Perio, Regis Gayon, Hélène Ternet-Fontebasso, Gilles Ferry, Françoise Nepveu, Jean A. Boutin, Jan Sudor, Karine Reybier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
NQO2
UGT1A6
conjugation
glucuronide
menadiol
cellular toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.660641/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.660641/full

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