CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression

CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression

Nerve/glial antigen (NG)2 expression crucially determines the aggressiveness of glioblastoma multiforme (GBM). Recent evidence suggests that protein kinase CK2 regulates NG2 expression. Therefore, we investigated in the present study whether CK2 inhibition suppresses proliferation and migration of N...

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Bibliographic Details
Main Authors: Beate M. Schmitt, Anne S. Boewe, Claudia Götz, Stephan E. Philipp, Steffi Urbschat, Joachim Oertel, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
glioblastoma multiforme
GBM
nerve/glial antigen 2
NG2
CK2
CX-4945
Online Access:https://www.mdpi.com/2072-6694/13/7/1678

Internet

https://www.mdpi.com/2072-6694/13/7/1678

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