Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells

Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells

Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but these often have ototoxic side effects due to the accumulation of oxygen-free radicals and the subsequent induction of HC ap...

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Bibliographic Details
Main Authors: Song Gao, Cheng Cheng, Maohua Wang, Pei Jiang, Liyan Zhang, Ya Wang, Huihui Wu, Xuanfu Zeng, Hui Wang, Xia Gao, Yongming Ma, Renjie Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
aminoglycoside
hair cell
blebbistatin
apoptosis
ROS
hearing
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00590/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00590/full

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