Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease

Previous studies demonstrated that the PKR (double-stranded RNA-activated protein kinase) pathway was activated while the mTOR (mammalian target of rapamycin) pathway was inhibited in Alzheimer’s disease (AD). Here, we analysed upstream and downstream factors of mTOR in brain of APPSL/PS1 KI mice di...

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Bibliographic Details
Main Authors: Milena Damjanac, Agnès Rioux Bilan, Marc Paccalin, Raymond Pontcharraud, Bernard Fauconneau, Jacques Hugon, Guylène Page
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Neurobiology of Disease
Subjects:
mTOR
Akt/PKB
p70/85S6K
Alzheimer’s disease
Translation
Mouse transgenic model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002240

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http://www.sciencedirect.com/science/article/pii/S0969996107002240

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