Macrophage and T cell produced IL-10 promotes viral chronicity.

Macrophage and T cell produced IL-10 promotes viral chronicity.

Chronic viral infections lead to CD8(+) T cell exhaustion, characterized by impaired cytokine secretion. Presence of the immune-regulatory cytokine IL-10 promotes chronicity of Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 infection, while absence of IL-10/IL-10R signaling early during infectio...

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Bibliographic Details
Main Authors: Kirsten Richter, Guillaume Perriard, Rayk Behrendt, Reto A Schwendener, Veronika Sexl, Robert Dunn, Masahito Kamanaka, Richard A Flavell, Axel Roers, Annette Oxenius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3820745?pdf=render

Internet

http://europepmc.org/articles/PMC3820745?pdf=render

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