Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Abstract The high prices of biopharmaceuticals or biologics used in the treatment of many diseases limit the access of patients to these novel therapies. One example is the monoclonal antibody trastuzumab, successfully used for breast cancer treatment. An economic alternative is the generation of bi...

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Bibliographic Details
Main Authors: Thailin Lao-Gonzalez, Alexi Bueno-Soler, Arnelys Duran-Hernandez, Katya Sosa-Aguiar, Luis Eduardo Hinojosa-Puerta, Tays Hernandez-Garcia, Kathya Rashida de la Luz-Hernandez, Julio Palacios-Oliva, Tammy Boggiano-Ayo
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:AMB Express
Subjects:
Biosimilar
Trastuzumab
CHO-K1 cells
Lentivirus
Intracellular staining
Flow cytometry
Online Access:https://doi.org/10.1186/s13568-020-01157-6

Internet

https://doi.org/10.1186/s13568-020-01157-6

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