Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

BRCA2 (also known as FANCD1) is a core component of the Fanconi pathway and suppresses transformation of immature T-cells in mice. However, the contribution of Fanconi-BRCA pathway deficiency to human T-cell acute lymphoblastic leukemia (T-ALL) remains undefined. We identified point mutations in 9 (...

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Bibliographic Details
Main Authors: Gayle P Pouliot, James Degar, Laura Hinze, Bose Kochupurakkal, Chau D Vo, Melissa A Burns, Lisa Moreau, Chirag Ganesa, Justine Roderick, Sofie Peirs, Bjorn Menten, Mignon L Loh, Stephen P Hunger, Lewis B Silverman, Marian H Harris, Kristen E Stevenson, David M Weinstock, Andrew P Weng, Pieter Van Vlierberghe, Alan D D'Andrea, Alejandro Gutierrez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221288

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