The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation

Severe appetite and weight loss define the eating disorder anorexia nervosa, and can also accompany the progression of some neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and...

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Bibliographic Details
Main Authors: Dennis Y. Kim, Joanna Yu, Ryan K. Mui, Rieko Niibori, Hamza Bin Taufique, Rukhsana Aslam, John W. Semple, Sabine P. Cordes
Format: Article
Language:English
Published: The Company of Biologists 2017-05-01
Series:Disease Models & Mechanisms
Subjects:
Eating disorder
RNA localization
Appetite regulation
Neurodegeneration
Npy
Modifier
Transgenic rescue
Online Access:http://dmm.biologists.org/content/10/5/581

Internet

http://dmm.biologists.org/content/10/5/581

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