Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that se...

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Bibliographic Details
Main Authors: Xiaoqian Zhang, Jin Feng, Shasha Chen, Haoyan Yang, Zhongjun Dong
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13032-5