The Emerging Nexus of Active DNA Demethylation and Mitochondrial Oxidative Metabolism in Post-Mitotic Neurons

The Emerging Nexus of Active DNA Demethylation and Mitochondrial Oxidative Metabolism in Post-Mitotic Neurons

The variable patterns of DNA methylation in mammals have been linked to a number of physiological processes, including normal embryonic development and disease pathogenesis. Active removal of DNA methylation, which potentially regulates neuronal gene expression both globally and gene specifically,...

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Bibliographic Details
Main Authors: Huan Meng, Guiquan Chen, Hui-Ming Gao, Xiaoyu Song, Yun Shi, Liu Cao
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
active DNA demethylation
mitochondrial oxidative metabolism
TET (ten-eleven translocation) methylcytosine dioxygenases
post-mitotic neurons
neurodegeneration
Online Access:http://www.mdpi.com/1422-0067/15/12/22604

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http://www.mdpi.com/1422-0067/15/12/22604

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