Activating PER repressor through a DBT-directed phosphorylation switch.

Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of certain proteins that constitute the biological clock. This study examines the role of the protein kinase Doubletime (DBT), a Drosophila ortholo...

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Bibliographic Details
Main Authors: Saul Kivimäe, Lino Saez, Michael W Young
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18666831/pdf/?tool=EBI