Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular...

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Bibliographic Details
Main Authors: Cardini Benno, Oberhuber Rupert, Hein Sven R., Watschinger Katrin, Hermann Martin, Obrist Peter, Werner-Felmayer Gabriele, Brandacher Gerald, Pratschke Johann, Werner Ernst R., Maglione Manuel
Format: Article
Language:English
Published: De Gruyter 2013-06-01
Series:Pteridines
Subjects:
animal model
ischemia-reperfusion injury
nitric oxide
organ transplantation
tetrahydrobiopterin
enzymes: calpain (ec 3.4.22.52); catalase (ec 1.11.1.6); glutathione peroxidase (ec 1.11.1.9); nadph oxidase (ec 1.6.3.1); nitric oxide reductase (ec 1.7.99.7); nitric oxide synthase (ec 1.14.13.39); phospholipase a2; (ec 3.1.1.4); superoxide dismutase (ec 1.15.1.1); xanthine oxidase (ec 1.17.3.2).
Online Access:https://doi.org/10.1515/pterid-2013-0006

Internet

https://doi.org/10.1515/pterid-2013-0006

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