Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans
The folate biosynthetic pathway is a promising and understudied source for novel antifungals. Even dihydrofolate reductase (DHFR), a well-characterized and historically important drug target, has not been conclusively validated as an antifungal target. Here, we demonstrate that repression of DHFR in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2020-06-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://doi.org/10.1128/mSphere.00374-20 |