CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells

CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells

Background: Cystic Fibrosis (CF) is a genetic disease in which the intestine exhibits oxidative and inflammatory markers. As mitochondria are the central source and the main target of reactive oxygen species, we hypothesized that cystic fibrosis transmembrane conductance regulator (CFTR) defect lead...

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Bibliographic Details
Main Authors: Marie L. Kleme, Alain Sané, Carole Garofalo, Ernest Seidman, Emmanuelle Brochiero, Yves Berthiaume, Emile Levy
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Nutrients
Subjects:
cystic fibrosis
fatty acid oxidation
OXPHOS
oxidative stress
apoptosis
lipid metabolism
apolipoprotein biogenesis
lipoprotein secretion
Online Access:http://www.mdpi.com/2072-6643/10/7/836

Internet

http://www.mdpi.com/2072-6643/10/7/836

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