Multi-Stress Induction of the <i>Mycobacterium tuberculosis</i> MbcTA Bactericidal Toxin-Antitoxin System

Multi-Stress Induction of the <i>Mycobacterium tuberculosis</i> MbcTA Bactericidal Toxin-Antitoxin System

MbcTA is a type II toxin/antitoxin (TA) system of <i>Mycobacterium tuberculosis</i>. The MbcT toxin triggers mycobacterial cell death in vitro and in vivo through the phosphorolysis of the essential metabolite NAD<sup>+</sup> and its bactericidal activity is neutralized by ph...

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Bibliographic Details
Main Authors: Kanchiyaphat Ariyachaokun, Anna D. Grabowska, Claude Gutierrez, Olivier Neyrolles
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Toxins
Subjects:
tuberculosis
toxin-antitoxin systems
bacterial cell death
NAD<sup>+</sup>
stress-response
Online Access:https://www.mdpi.com/2072-6651/12/5/329

Internet

https://www.mdpi.com/2072-6651/12/5/329

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