AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

The receptor tyrosine kinase (RTK) AXL is induced in response to type I interferons (IFNs) and limits their production through a negative feedback loop. Enhanced production of type I IFNs in Axl-/- dendritic cells (DCs) in vitro have led to speculation that inhibition of AXL would promote antiviral...

Full description

Bibliographic Details
Main Authors: Edward T Schmid, Iris K Pang, Eugenio A Carrera Silva, Lidia Bosurgi, Jonathan J Miner, Michael S Diamond, Akiko Iwasaki, Carla V Rothlin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
AXL RTK
dendritic cell
type I interferons
IL-1β
influenza A virus
West Nile virus
Online Access:https://elifesciences.org/articles/12414

Internet

https://elifesciences.org/articles/12414

Similar Items