Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome

Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Cyclophilin A (CYPA) is upregulated in EBV-associated nasopharyngeal carcinoma (NPC) with unknown roles. In the present approach, cytosolic CYPA was f...

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Bibliographic Details
Main Authors: Shuyu Xin, Shujuan Du, Lingzhi Liu, Yan Xie, Lielian Zuo, Jing Yang, Jingjin Hu, Wenxing Yue, Jing Zhang, Pengfei Cao, Fanxiu Zhu, Jianhong Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Microbiology
Subjects:
Epstein-Barr virus nuclear antigen 1
latent genome
cyclophilin A
replication
persistence
pathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02879/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02879/full

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