A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network

In this paper we develop a novel mathematical model of the insulin-TOR-MAPK signaling network that controls growth. Most data on the properties of the insulin and MAPK signaling networks are static and the responses to experimental interventions, such as knockouts, overexpression, and hormonal inpu...

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Bibliographic Details
Main Authors: H. Frederik Nijhout, Viviane eCallier
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00245/full