Intrinsic patterns of coupling between correlation and amplitude of low-frequency fMRI fluctuations are disrupted in degenerative dementia mainly due to functional disconnection.

Low frequency fluctuations (LFFs) of the BOLD signal are a major discovery in the study of the resting brain with functional magnetic resonance imaging (fMRI). Two fMRI-based measures, functional connectivity (FC), a measure of signal synchronicity, and the amplitude of LFFs (ALFF), a measure of sig...

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Bibliographic Details
Main Authors: Daniele Mascali, Mauro DiNuzzo, Tommaso Gili, Marta Moraschi, Michela Fratini, Bruno Maraviglia, Laura Serra, Marco Bozzali, Federico Giove
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4386762?pdf=render