Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?

Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?

Abstract Background Loss of paternal methylation (LOM) of the H19/IGF2 intergenic differentially methylated region (H19/IGF2:IG-DMR) causes alteration of H19/IGF2 imprinting and Silver-Russell syndrome (SRS). Recently, internal deletions of the H19/IGF2:IG-DMR have been associated with LOM and SRS w...

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Bibliographic Details
Main Authors: Angela Sparago, Flavia Cerrato, Andrea Riccio
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Clinical Epigenetics
Subjects:
Genomic imprinting
Silver-Russell syndrome
DNA methylation
ZFP57
H19/IGF2:IG-DMR deletions
Beckwith-Wiedemann syndrome
Online Access:http://link.springer.com/article/10.1186/s13148-018-0454-7

Internet

http://link.springer.com/article/10.1186/s13148-018-0454-7

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