Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF

Abstract Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homogenates has been quantified with “biosensor” cell lines that express tau with a dis...

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Bibliographic Details
Main Authors: Brian D. Hitt, Jaime Vaquer-Alicea, Victor A. Manon, Joshua D. Beaver, Omar M. Kashmer, Jan N. Garcia, Marc I. Diamond
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau
Seeding
Cerebrospinal fluid
Biomarkers
Online Access:https://doi.org/10.1186/s40478-021-01185-8

Internet

https://doi.org/10.1186/s40478-021-01185-8

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