Nox4 Facilitates TGFβ1-Induced Fibrotic Response in Human Tenon’s Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery

Nox4 Facilitates TGFβ1-Induced Fibrotic Response in Human Tenon’s Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery

Collagen accumulation in sub-conjunctival tissue at the surgical wound is one of the major complications associated with glaucoma filtration surgery (GFS). This process often leads to unwanted fibrotic scar formation at the lesion site and dysfunction of tissues. Previously, we demonstrated that NAD...

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Bibliographic Details
Main Authors: Manisha H. Shah, Elsa C. Chan, Nicole J. Van Bergen, Surinder S. Pandav, Sze Ng, Jonathan G. Crowston, Hitesh M. Peshavariya
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
collagen
glaucoma filtration surgery
NADPH Oxidase
transforming growth factor-beta
reactive oxygen species
Online Access:https://www.mdpi.com/2076-3921/9/11/1126

Internet

https://www.mdpi.com/2076-3921/9/11/1126

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