Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation

Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their anti-tumor effector functions and potential for allogeneic use, various NK cell platforms are being examined for adoptive cell therapies. Howe...

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Bibliographic Details
Main Authors: Hemant K. Mishra, Kate J. Dixon, Nabendu Pore, Martin Felices, Jeffrey S. Miller, Bruce Walcheck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.711621/full