An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer

An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer

Abstract We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxi...

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Bibliographic Details
Main Authors: Gitanjali Asampille, Brijesh Kumar Verma, Monalisa Swain, Abhijith Shettar, Steven A. Rosenzweig, Paturu Kondaiah, Hanudatta S. Atreya
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Nanobiotechnology
Subjects:
Protein nanotube
Self-assembly
Intermolecular disulfide bonds
RGD motif
Integrin targeting
Cancer
Online Access:http://link.springer.com/article/10.1186/s12951-018-0427-1

Internet

http://link.springer.com/article/10.1186/s12951-018-0427-1

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