Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma

Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma

Abstract Aberrant epigenetic reprogramming represents a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression. Whether there existed other epigenetic vulnerabilities that could serve as therapeutic targets remained unclear and promising. Here, we combined the clustered regularly inter...

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Bibliographic Details
Main Authors: Chuanjie Zhang, Xuan Lu, Jingyi Huang, Hongchao He, Li Chen, Yihan Liu, Haofei Wang, Yang Xu, Siwei Xing, Xiaohao Ruan, Xiaoqun Yang, Lu Chen, Danfeng Xu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
epigenetic vulnerability
JMJD6
sunitinib
super‐enhancers
Online Access:https://doi.org/10.1002/ctm2.328

Internet

https://doi.org/10.1002/ctm2.328

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