Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds

Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds

Given the limited efficacy of current medical treatments in trauma-related necrotizing mucormycosis, there is a dire need to better understand the Mucoralean pathophysiology in order to develop novel strategies to counteract fungal tissue invasion following severe trauma. Here, we describe that torn...

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Bibliographic Details
Main Authors: Sebastian Wurster, Alexander M. Tatara, Nathaniel D. Albert, Ashraf S. Ibrahim, Joseph Heitman, Soo Chan Lee, Amol C. Shetty, Carrie McCracken, Karen T. Graf, Antonios G. Mikos, Vincent M. Bruno, Dimitrios P. Kontoyiannis
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
mucormycosis
virulence
mechanobiology
trauma
stress response
Online Access:https://doi.org/10.1128/mBio.01414-20

Internet

https://doi.org/10.1128/mBio.01414-20

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