A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant. Theoretical studies of the reactivity of trifluoroacetonitrile oxide 4 toward olefins and alkynes were carried out. The...

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Bibliographic Details
Main Authors: Raoni S. B. Gonçalves, Michael Dos Santos, Guillaume Bernadat, Danièle Bonnet-Delpon, Benoit Crousse
Format: Article
Language:English
Published: Beilstein-Institut 2013-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aldoxime
amino alcohol
fluorine
isoxazole
isoxazoline
organo-fluorine
Online Access:https://doi.org/10.3762/bjoc.9.275

Internet

https://doi.org/10.3762/bjoc.9.275

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