A General Protein O-Glycosylation Gene Cluster Encodes the Species-Specific Glycan of the Oral Pathogen Tannerella forsythia: O-Glycan Biosynthesis and Immunological Implications

A General Protein O-Glycosylation Gene Cluster Encodes the Species-Specific Glycan of the Oral Pathogen Tannerella forsythia: O-Glycan Biosynthesis and Immunological Implications

The cell surface of the oral pathogen Tannerella forsythia is heavily glycosylated with a unique, complex decasaccharide that is O-glycosidically linked to the bacterium’s abundant surface (S-) layer, as well as other proteins. The S-layer glycoproteins are virulence factors of T. forsythia and ther...

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Bibliographic Details
Main Authors: Markus B. Tomek, Daniel Maresch, Markus Windwarder, Valentin Friedrich, Bettina Janesch, Kristina Fuchs, Laura Neumann, Irene Nimeth, Nikolaus F. Zwickl, Juliane C. Dohm, Arun Everest-Dass, Daniel Kolarich, Heinz Himmelbauer, Friedrich Altmann, Christina Schäffer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
carbohydrate-active enzymes
glycosyltransferase
immunogenicity
locus for glycosylation
methyltransferase
periodontitis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02008/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02008/full

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