Functional Consequences of 17q21.31/WNT3-WNT9B Amplification in hPSCs with Respect to Neural Differentiation

Functional Consequences of 17q21.31/WNT3-WNT9B Amplification in hPSCs with Respect to Neural Differentiation

Human pluripotent stem cell (hPSC) lines exhibit repeated patterns of genetic variation, which can alter in vitro properties as well as suitability for clinical use. We examined associations between copy-number variations (CNVs) on chromosome 17 and hPSC mesodiencephalic dopaminergic (mDA) different...

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Bibliographic Details
Main Authors: Chun-Ting Lee, Raphael M. Bendriem, Abigail A. Kindberg, Lila T. Worden, Melanie P. Williams, Tomas Drgon, Barbara S. Mallon, Brandon K. Harvey, Christopher T. Richie, Rebecca S. Hamilton, Jia Chen, Stacie L. Errico, Shang-Yi A. Tsai, George R. Uhl, William J. Freed
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714011036

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http://www.sciencedirect.com/science/article/pii/S2211124714011036

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